Osteoporosis: Mechanism, Molecular Target and Current Status on Drug Development

Drug development in pediatric psychiatry: current status, future trends

Introduction Reflecting the fact that regulatory agencies recently required companies to initiate a pediatric drug development plan earlier in the drug development sequence for compounds first developed for adults, most psychiatric drugs for children still remain the offspring of adult drug development programs, viz., except for the psychostimulants, very few psychiatric medications have been d...

Nanotechnology Based Targeted Drug Delivery: Current Status and Future Prospects for Drug Development

Current and potential future drug treatments for osteoporosis.

There has been a major interest in the drug treatment of osteoporosis and an increase in the number of drugs available in most countries. The ideal drug (one which increases or restores bone density and trabecular connectivity) is still not available. However, in patients with relatively preserved trabecular connectivity and moderately reduced bone density, several agents have shown substantial...

the effects of high non fibrous carbohydrates diet on milk production, inflammation and molecular mechanism of innate immunity in lactating dairy cows

پژوهش حاضر با هدف بررسی اثر جیره حاوی کربوهیدراتهای غیرالیافی زیاد و بروز التهاب در گاوهای شیرده در دو آزمایش جداگانه انجام شد. در آزمایش اول 20 رأس گاو مبتلا به ورم پستان از دو گروه کم تولید و پرتولید (هر کدام 10 رأس) و 20 رأس گاو سالم از دو گروه کم تولید و پرتولید (هر کدام 10 رأس) انتخاب شدند. همه گاوها در دوره دوم و یا سوم شیردهی و در روزهای 80-120 پس از زایش بودند. میانگین تولید شیر در گروه...

Development of target focused library against drug target of P. falciparum using SVM and Molecular docking

PfHslV, a homolog of b subunit of 20S proteasome forms the proteolytic core of the PfHslUV machinery in P. falciparum [1,2]. PfHslV has no homolog in the human host and it is a promising drug target essential to the plasmodial metabolism. The use of single proteasome inhibitor targeting these threonine proteases has a potential to be antimalarial drug candidate. One of our recent studies identi...